
The course is designed to help learners understand the neurological basis of various diseases and disorders, including Parkinson's disease, multiple sclerosis, and epilepsy.
The course covers topics such as neural development, the anatomy and physiology of the nervous system, synaptic transmission, sensory and motor systems, and neural plasticity. Learners will also explore the effects of drugs on the nervous system and the relationship between the brain and behavior.
The course is structured into 13 weeks, each containing several video lectures, readings, and quizzes. Learners will also have the opportunity to participate in peer-reviewed assignments and discussions with their classmates.
By the end of the course, learners will have gained a comprehensive understanding of the human nervous system and its relationship to various medical conditions. They will also be equipped with the knowledge and skills necessary to critically evaluate current research in the field of neuroscience.
Course Content:
Medical Neuroscience explores the functional organization and neurophysiology of the human central nervous system, while providing a neurobiological framework for understanding human behavior. In this course, you will discover the organization of the neural systems in the brain and spinal cord that mediate sensation, motivate bodily action, and integrate sensorimotor signals with memory, emotion and related faculties of cognition. The overall goal of this course is to provide the foundation for understanding the impairments of sensation, action and cognition that accompany injury, disease or dysfunction in the central nervous system. The course will build upon knowledge acquired through prior studies of cell and molecular biology, general physiology and human anatomy, as we focus primarily on the central nervous system.
This online course is designed to include all of the core concepts in neurophysiology and clinical neuroanatomy that would be presented in most first-year neuroscience courses in schools of medicine. However, there are some topics (e.g., biological psychiatry) and several learning experiences (e.g., hands-on brain dissection) that we provide in the corresponding course offered in the Duke University School of Medicine on campus that we are not attempting to reproduce in Medical Neuroscience online. Nevertheless, our aim is to faithfully present in scope and rigor a medical school caliber course experience.
The Medical Neuroscience course on Coursera, authored by Leonard E. White, consists of 13 weeks, each of which includes multiple video lectures, readings, and quizzes. Here is a more detailed breakdown of the course content:
Week 1:
Getting Started in Medical Neuroscience
Let's get started in Medical Neuroscience! Each module in Medical Neuroscience will begin with a brief description like this that provides you with an overview of the module. In this first module, you will get to know something about Prof. White and his career in neuroscience; you will understand the scope of Medical Neuroscience, its learning resources, your responsibilities for maximizing your benefit in this course, and you will learn Prof. White's tips on how best to study and learn.</p><p> At the end of this module, please take the ungraded preliminary quiz, "Are you ready for Medical Neuroscience", to self-assess your background knowledge. Your score on this quiz will not count toward your overall score in this course. However, you should be able to pass this quiz (score 70% or better) if you are ready for the academic challenge of this course. Students who are likely to achieve their goals in Medical Neuroscience should be able to successfully answer nearly all of the quiz questions on their first attempt and feel comfortable with assessment questions at this level of knowledge.
5 videos (Total 75 min), 2 readings, 1 quiz
Professor White's Career in Neuroscience 13m
The Scope of Medical Neuroscience 11m
Learning resources for Medical Neuroscience 32m
Your Part! 13m
"Neur-run" with Professor White 3m
Learning Objectives 10m
Your Mentor Team 10m
Preliminary Quiz: Are you ready for Medical Neuroscience? 30m
Neuroanatomy: Introducing the Human Brain
4 videos (Total 79 min), 1 reading, 1 quiz
Professor White's Favorite Places in the Human Brain 19m
Functional Microanatomy of Neurons 31m
Non-Neural Cells of the CNS 20m
Basic Orientation in the Human CNS 7m
Introduction, Learning Objectives and Recommended Reading 10m
Cells of the CNS and Basic Orientation 30m
Week 2:
Neuroanatomy: Surface Anatomy of the Human CNS
12 videos (Total 129 min), 2 readings, 2 quizzes
Lateral Surface of the Brain 6m
Medial Surface of the Brain 5m
Finding the Central Sulcus6mVentral Surface of the Brain 8m
Building a Digital Brain (Fingers to Gyri) 11m
Surface Anatomy of the Brainstem4mBlood Supply to the Brain 15m
Overview of the Cranial Nerves 19m
Overview of the Spinal Nerves 8m
Localizing the Cranial Nerves 13m
Cranial Nerve Function, part1 16m
Cranial Nerve Function, part2 11m
Learning Objectives / Recommended Readings 10m
Learning Objectives / Recommended Readings 10m
Cerebral Cortex, Brainstem, and Blood Supply 30m
Cranial and Spinal Nerves 30m
Neuroanatomy: Internal Anatomy of the Human CNS
12 videos (Total 160 min), 2 readings, 2 quizzes
Internal Anatomy of the Brainstem 24m
Cranial Nerve Nuclei, part1 12m
Cranial Nerve Nuclei, part2 19m
Cranial Nerve Nuclei, part3 17m
Cranial Nerve Nuclei, part4 17m
Internal Anatomy of the Spinal Cord - Gray and White Matter 11m
Internal Anatomy of the Spinal Cord -Longitudinal Organization 11m
Internal Anatomy of the Spinal Cord In Cross Sections6m
Ventricles 8m
Overview of the Internal Capsule and Deep Gray Matter 8m
Localizing the Internal Capsule and Deep Gray Matter In Brain Slabs 9m
Localizing the Internal Capsule and Deep Gray Matter In Sylvius Atlases 12m
Learning Objectives / Recommended Readings 10m
Learning Objectives / Recommended Readings 10m
Brainstem and Spinal Cord 22m
Forebrain 30m
Week 3: Neural Signaling: Electrical Excitability and Signal Propagation
9 videos (Total 142 min), 1 reading, 1 quiz
Overview of Neuronal Signaling 14m
Ionic Basis of the Resting Membrane Potential, part1 14m
Ionic Basis of the Resting Membrane Potential, part2 15m
Ionic Basis of the Action Potential, part1 18m
Ionic Basis of the Action Potential, part2 12m
Ionic Basis of the Action Potential, part3 15m
Molecular Mechanisms of Action Potential Generation, part1 20m
Molecular Mechanisms of Action Potential Generation, part2 9m
Propagation of Action Potentials 20m
Learning Objectives / Recommended Readings 10m
Generating and Propagating Electrical Signals 30m
Week 4: Neural Signaling: Synaptic Transmission and Synaptic Plasticity
13 videos (Total 226 min), 2 readings, 2 quizzes
Synaptic Transmission, part 1 21m
Synaptic Transmission, part 215m
Neurotransmitters, part 115m
Neurotransmitters, part 222m
Ionotropic Neurotransmitters Receptors, part 117m
Ionotropic Neurotransmitters Receptors, part 211m
Metabotropic Neurotransmitters Receptors and Postsynaptic Mechanisms11m
Synaptic Integration25m
Long-Term Potentiation and Depression, part 122m
Long-Term Potentiation and Depression, part 217m
Long-Term Potentiation and Depression, part 314m
Spike-Timing Dependent synaptic Plasticity19m
Hebb's Postulate11m
Learning Objectives / Recommended Readings 10m
Learning Objectives / Recommended Readings 10m
Synaptic Transmission 30m
Synaptic Plasticity 30m
Week 5: Sensory Systems: General Principles and Somatic Sensation
16 videos (Total 257 min), 2 readings, 2 quizzes
The Thalamus 15m
Overview and Origins of Cortical Circuits, part1 16m
Overview and Origins of Cortical Circuits, part2 11m
General Principles of Sensory Systems, part1 17m
General Principles of Sensory Systems, part2 18m
Mechanosensation, part1 16m
Mechanosensation, part2 15m
Mechanosensation, part3 16m
Mechanosensory Pathways, part1 15m
Mechanosensory Pathways, part2 11m
Mechanosensory Pathways, part3 17m
Pain Systems, part1 19m
Pain Systems, part2 15m
Pain Systems, part3 13m
Pain and Temperature Pathways, part1 19m
Pain and Temperature Pathways, part2 17m
Learning Objectives / Recommended Readings 10m
Learning Objectives / Recommended Readings 10m
Organizing Principles30mSomatic Sensation 30m
Week 6: Sensory Systems: The Visual System
This module will provide lessons that are designed to help you understand the basic mechanisms by which light is transduced into electrical signals that are then used to construct visual perceptions in the brain. Your studies of the visual system will benefit you at this point in the course, but also in later studies when we use the visual system as a model for understanding general principles of developmental plasticity. Lastly, it is worth noting how much of the forebrain contains elements of the visual pathways. Thus, injuries and disease in widespread regions of the brain may have a clinically important impact on visual function. All the more reason to learn these lessons well as you progress in Medical Neuroscience.
12 videos (Total 161 min), 2 readings, 2 quizzes
Basic Structure of the Eye and Retina 16m
Photoreceptors and Phototransduction, part1 14m
Photoreceptors and Phototransduction, part2 11m
Ganglion Cell Receptive fields, part1 13m
Ganglion Cell Receptive fields, part2 6m
Central Visual Processing, part1 14m
Central Visual Processing, part2 15m
Central Visual Processing, part3 19m
Central Visual Pathways, part1 12m
Central Visual Pathways, part2 13m
Visual Field Deficits 15m
Pupillary Light Reflex 9m
Learning Objectives / Recommended Readings 10m
Learning Objectives / Recommended Readings 10m
The Eye 30m
Central Visual Processing 30m
Week 7: Sensory Systems: Audition, Vestibular Sensation and the Chemical Senses
22 videos (Total 272 min), 3 readings, 3 quizzes
Peripheral Auditory Mechanisms, part 1 18m
Peripheral Auditory Mechanisms, part2 13m
Peripheral Auditory Mechanisms, part3 10m
Central Auditory Processing, part1 14m
Central Auditory Processing, part2 11m
Central Auditory Processing, part1 15m
Peripheral Vestibular Mechanisms, part1 16m
Peripheral Vestibular Mechanisms, part2 14m
Peripheral Vestibular Mechanisms, part3 12m
Central Vestibular Processing, part1 8m
Central Vestibular Processing, part2 12m
Central Vestibular Processing, part3 12m
Central Vestibular Processing, part4 4m
Overview of the Chemical Senses 8m
Olfaction, part1 13m
Olfaction, part2 9m
Olfaction, part3 14m
Olfaction, part4 18m
Gustation, part1 11m
Gustation, part2 14m
Gustation, part3 9m
Trigeminal Chemoreception 10m
Learning Objectives / Recommended Readings 10m
Learning Objectives / Recommended Readings 10m
Learning Objectives / Recommended Readings 10m
Audition 30m
Vestibular Sensation 30m
Chemical Senses 30m
Week 8:
Movement and Motor Control: Lower and Upper Motor Neurons
18 videos (Total 252 min), 2 readings, 2 quizzes
Overview of the Motor System 14m
Overview of Motor Units 20m
Muscle Spindles and Myotatic Reflexes, part1 18m
Muscle Spindles and Myotatic Reflexes, part2 11m
Golgi Tendon Organs 7m
Spindles Versus GTOs, and Withdrawal Reflexes 9m
Central Pattern Generation 8m
Lower Motor Syndrome 5m
Primary Motor Cortex, part1 19m
Primary Motor Cortex, part2 15m
Primary Motor Cortex, part3 11m
Premotor Cortex 14m
Brainstem Upper Motor Neurons 15m
Emotional Motor System 15m
Control of Facial Expressions 22m
Upper Motor Neuron Syndrome 8m
Corticospinal and Corticobulbar Pathways, part1 18m
Corticospinal and Corticobulbar Pathways, part2 14m
Learning Objectives / Recommended Readings 10m
Learning Objectives / Recommended Readings 10m
Lower Motor Neuronal Control of Movement 30m
Upper Motor Neuronal Control of Movement 30m
Movement and Motor Control: Understanding the Paradigm of Eye Movements
6 videos (Total 60 min), 1 reading, 1 quiz
Overview of Eye Movements 8m
Conjugate Eye Movements 9m
Disconjugate Eye Movements and Eye Movement Physiology 10m
Neural Control of Saccades, part1 10m
Neural Control of Saccades, part2 10m
Learning Objectives / Recommended Readings 10m
Eye Movements 30m
Week 9:
Movement and Motor Control: Modulation of Movement
11 videos (Total 154 min), 2 readings, 2 quizzes
Circuitry of the Basal Ganglia, part 1 17m
Circuitry of the Basal Ganglia, part2 13m
Circuitry of the Basal Ganglia, part3 14m
Function of Basal Ganglia Circuitry 17m
Basal Ganglia Function In Normal and Abnormal Movement 19m
Overview of the Cerebellum, part1 11m
Overview of the Cerebellum, part2 12m
Cerebellar Circuits, part1 11m
Cerebellar Circuits, part2 14m
Cerebellar Circuits, part3 6m
Cerebellar Function In Normal and Abnormal Movement 15m
Learning Objectives / Recommended Readings 10m
Learning Objectives / Recommended Readings 10m
Modulation of Movement by the Basal Ganglia 30m
Modulation of Movement by the Cerebellum 30m
Movement and Motor Control: Visceral Motor Control
8 videos (Total 107 min), 1 reading, 1 quiz
Functional and Anatomical Divisions of the Visceral Motor System, part 1 11m
Functional and Anatomical Divisions of the Visceral Motor System, part2 13m
Functional and Anatomical Divisions of the Visceral Motor System, part3 10m
Central Integration of Visceral Sensory and Motor Signals, part1 13m
Central Integration of Visceral Sensory and Motor Signals, part2 7m
Hypothalamus, part1 14m
Hypothalamus, part2 16m
Micturition 19m
Learning Objectives / Recommended Readings 10m
Visceral Motor System 30m
Week 10: The Changing Brain: The Brain Across the Lifespan
23 videos (Total 295 min), 3 readings, 3 quizzes
Embryological Subdivisions of the Human CNS 8m
Major Forces In Early Brain Development 12m
Neurulation 11m
Formation of the Early CNS 12m
Inductive Signaling In CNS Formation 15m
Proliferation and Migration, part1 17m
Proliferation and Migration, part2 10m
Growth Cones 11m
Molecular Signals for Axon Guidance, part1 13m
Molecular Signals for Axon Guidance, part2 12m
Neurotrophins 13m
Neurotrophin Receptors and Synapse Formation 11m
Lessons from Studies of Ocular Dominance Columns, part1 21m
Lessons from Studies of Ocular Dominance Columns, part2 11m
Lessons from Studies of Orientation and Direction Preference, part1 15m
Lessons from Studies of Orientation and Direction Preference, part2 10m
Lessons from Studies of Orientation and Direction Preference, part3 16m
Neurotrophins In Developmental Plasticity 12m
Brain Development Across the Lifespan, part1 12m
Brain Development Across the Lifespan, part2 7m
Functional Plasticity In Cortical Maps 16m
Repair and Regeneration, part1 13m
Repair and Regeneration, part2 6m
Learning Objectives / Recommended Readings 10m
Learning Objectives / Recommended Readings 10m
Learning Objectives / Recommended Readings 10m
Early Brain Development 30m
Developmental Plasticity of Neural Circuits In Early Life 30m
Development, Repair and Regeneration Across the Lifespan 30m
Week 11: Complex Brain Functions: Associational Cortex
11 videos (Total 169 min), 1 reading, 1 quiz
Overview of the Associational Cortex 13m
Parietal Associational Cortex, part1 12m
Parietal Associational Cortex, part2 14m
Temporal associational Cortex: Visual Recognition 21m
Temporal Associational Cortex: Memory, part1 23m
Temporal Associational Cortex: Memory, part2 11m
Temporal Associational Cortex: Language, part1 14m
Temporal Associational Cortex: Language, part2 11m
Frontal Associational Cortex: Working Memory 14m
Frontal Associational cortex: Exeutive Function 14m
Learning Objectives / Recommended Reading 10m
Associational Cortex 30m
Week 12: Complex Brain Functions: Sleep, Emotion and Addiction
13 videos (Total 205 min), 2 readings, 2 quizzes
Overview of Sleep and Wakefulness 18m
Circadian Rhythms 16m
Brain Waves and Sleep Stages 15m
Neural Circuits That Govern Sleep and Wakefulness, part1 19m
Neural Circuits That Govern Sleep and Wakefulness, part2 15m
Sleep Disorders 14m
Amygdala and Hippocampus In the Human Brain 5m
Neurobiology of Emotion, part1 15m
Neurobiology of Emotion, part2 13m
Neurobiology of Emotion, part3 20m
Neurobiology of Emotion, part4 22m
Reward and Addiction, part1 12m
Reward and Addiction, part2 13m
Learning Objectives / Recommended Readings 10m
Learning Objectives / Recommended Readings 10m
Sleep and Wakefulness 30m
Limbic Forebrain, Emotion, and Addiction 30m
Week 13:
Comprehensive Final Exam
1 video (Total 22 min), 1 reading, 5 quizzes
Preparing for the Comprehensive Final Exam 22m
Preparation Notes 10m
Example Clinical Case Quiz (UNGRADED, 11 questions) 30m
Comprehensive Final Exam, part 1 (2 cases, 13 questions) 30m
Comprehensive Final Exam, part 2 (2 cases, 7 questions) 30m
Comprehensive Final Exam, part 3 (2 cases, 11 questions) 30m
Comprehensive Final Exam, part 4 (2 cases, 12 questions) 30m
Closing Remarks
1 video (Total 6 min)
Closing Remarks from Dr. White (05:44) 5m
Reviews:
As a former student of the Medical Neuroscience course authored by Leonard E. White on Coursera, I found the course to be an excellent educational experience.
The course is designed to provide learners with a comprehensive overview of the field of neuroscience, covering topics such as the structure and function of neurons, the organization and function of the nervous system, and the relationship between the brain and behavior. The course is presented in an engaging and accessible manner, with clear and concise video lectures, helpful diagrams and animations, and challenging but manageable quizzes and assignments.
One of the strengths of the course is its emphasis on active learning. Learners are encouraged to participate in online discussion forums, to collaborate with their peers, and to engage in independent research to deepen their understanding of the course materials. The course instructors are responsive and supportive, providing helpful feedback on assignments and answering questions in a timely manner.
The course is also well-organized, with clear learning objectives and a logical progression of topics. The course materials are presented in a modular format, allowing learners to work at their own pace and to revisit material as needed. The course also includes a wealth of supplementary materials, including additional readings, videos, and interactive tools, that allow learners to explore topics in greater depth.
Overall, I would highly recommend the Medical Neuroscience course to anyone interested in the workings of the human brain. The course is accessible to learners with a range of backgrounds and experience levels, and the quality of the course materials and instruction is excellent. The course provides a solid foundation in neuroscience that is applicable to a range of fields, including medicine, psychology, and neuroscience research.
At the time, the course has an average ratings of 4.9 out of 5 stars based on over 2,586 ratings.
What you'll learn:
After completing the Medical Neuroscience course by Leonard E. White on Coursera, learners will have gained several key skills, including:
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Understanding the basic anatomy and physiology of the nervous system: Learners will gain a comprehensive understanding of the different structures and functions of the human nervous system, including the brain, spinal cord, and peripheral nerves. They will also learn about the organization of the nervous system and how different regions of the brain are involved in various functions.
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Recognizing the fundamental principles of electrical signaling in neurons: Learners will learn about the mechanisms involved in electrical signaling in neurons, including the role of ion channels, membrane potentials, and action potentials. They will also learn about the process of synaptic transmission, including the release of neurotransmitters and the mechanisms of synaptic plasticity.
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Identifying the different types of sensory systems and how they function: Learners will gain an understanding of the different sensory systems in the body, including the visual, auditory, olfactory, gustatory, and somatosensory systems. They will learn about the different types of sensory receptors and how they transduce stimuli, as well as the neural pathways involved in transmitting sensory information to the brain.
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Understanding the mechanisms involved in motor control and autonomic regulation: Learners will learn about the different types of motor neurons and how they control muscle contraction. They will also learn about the different types of reflexes and how they are regulated. In addition, learners will gain an understanding of the autonomic nervous system and how it regulates various bodily functions, such as heart rate and digestion.
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Evaluating the role of plasticity in the nervous system and its implications in disease and injury: Learners will learn about the mechanisms of neural plasticity, including long-term potentiation and long-term depression. They will also learn about the role of plasticity in learning and memory, as well as the ways in which plasticity can be affected by injury and disease.
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Analyzing the effects of drugs and addiction on the nervous system: Learners will gain an understanding of the different types of drugs and how they affect the nervous system. They will learn about the mechanisms of addiction and how they are related to neural circuits in the brain.
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Developing critical thinking skills to evaluate research in neuroscience and related fields: Throughout the course, learners will be encouraged to think critically about the scientific evidence presented in the lectures and readings. They will learn how to evaluate research studies and draw evidence-based conclusions.
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Improving their ability to communicate complex scientific concepts to a broader audience: Finally, learners will have the opportunity to participate in online discussions with other learners and develop their skills in communicating complex scientific concepts to a broader audience. They will also have the opportunity to complete a final project in which they create a video or podcast that communicates a neuroscience concept to a general audience.
Author:
Leonard E. White is a Professor of Neuroscience at Duke University School of Medicine, where he has been teaching and conducting research for over 30 years. He is also an active member of the Duke Institute for Brain Sciences and has served as the Director of Graduate Studies for the Neurobiology Graduate Program at Duke.
Dr. White's research focuses on the cellular and molecular mechanisms involved in neural development, specifically the formation of synapses and the differentiation of neuronal cell types. He has published numerous research papers in prestigious journals, such as Neuron, Nature Neuroscience, and The Journal of Neuroscience.
In addition to his research, Dr. White is an accomplished educator who has received several awards for his teaching, including the Golden Apple Award for Excellence in Teaching from the Duke School of Medicine. He is known for his engaging and dynamic teaching style, as well as his ability to communicate complex scientific concepts in a way that is accessible to learners at all levels.
Overall, Dr. White is a highly respected and knowledgeable expert in the field of neuroscience, with a wealth of experience both as a researcher and educator. His expertise and passion for the subject matter make him an excellent instructor for the Medical Neuroscience course on Coursera, and learners can expect to benefit greatly from his insights and expertise.
Requirements:
The Medical Neuroscience course, authored by Leonard E. White on Coursera, has the following requirements:
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Prior Knowledge: While a basic understanding of biology, chemistry, and neuroscience is recommended, it is not required. The course is designed to be accessible to learners with a range of backgrounds and experience levels.
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Technical Requirements: Access to a computer with a reliable internet connection is essential, as the course is entirely online. Learners will need to be able to stream video lectures, download and upload files, and participate in online discussion forums. Basic computer skills, such as proficiency in navigating web pages and using online communication tools, are necessary for successful completion of the course.
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Time Commitment: Learners will need to devote approximately 3-5 hours per week to the course, including watching video lectures, completing quizzes and assignments, and participating in discussion forums. While the course is self-paced, learners are encouraged to stay on schedule to maximize their learning experience.
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Language Requirements: The course materials, including video lectures, quizzes, and assignments, are presented in English. As such, learners should be comfortable with reading and writing in English.
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Course Materials: Learners will need access to a printer to print out course materials, such as notes and handouts. Additionally, some assignments may require the use of specialized software, such as MATLAB, which may require additional technical proficiency.
Overall, the Medical Neuroscience course is designed to be accessible to a wide range of learners, but a willingness to commit time and effort to the course is essential for successful completion.
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